½ÇÇè½Ç ³»¿¡¼ ¹è¾çµÈ ÆíÆò»óÇÇ¾Ï ¼¼Æ÷ÁÖ¿¡ ´ëÇÑ ¿°ÈºÒ¼ÒÀÇ È¿°ú
The effects of sodium fluroide on squamous cell carcioma cell line cultured in vitro
¹Ú³ëºÎ,
¼Ò¼Ó »ó¼¼Á¤º¸
¹Ú³ëºÎ ( ) - °è¸í´ëÇб³
KMID : 0360119960180020316
Abstract
The effects of Sodium Fluoride on squamous cell carcinoma cell line(SCC-cells) cultured in vitro have been studied with respect to cytotoxicity and induction of chromosome aberrations.
Cytotoxicity of NaF on SCC-cells, as determined by a decrease in colony-forming ability, linearly increased with dose of NaF(150-300 §¶/ml) or exposure time (3-24h).
SCC-cells treated with 30-60ug/ml NaF for 24h were analyzed for chromosome aberrations. A significant increase in the frequency of chromosome aberration at the chromatid level was induced by NaF in a dose-dependent manner.
These results suggest that NaF is a toxic substance which inhibit cell proliferation and causes DNA damage in SCC-cells cultured in Vitro.
Å°¿öµå
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸